Crédits ECTS |
3
|
Volume horaire total |
30
|
Volume horaire CM |
18
|
Volume horaire TD |
12
|
Volume horaire TP |
0
|
Pré-requis
Connaissances de base en biologie moléculaire, génétique
Basic knowledge of molecular biology and genetics
Objectifs
Connaissance des principaux mécanismes de régulation de l’expression des gènes : mécanismes de régulation transcriptionnel, post-transcriptionnel, traductionnel et post-traductionnel.
Knowledge of the main mechanisms of regulation of gene expression: transcriptional, post-transcriptional, translational and post-translational regulation mechanisms.
188比分直播
Lectures
-Control at the transcriptional level: eukaryotic transcription, transcription factors, chromatin and gene expression, euchromatic border regions, methylation and gene expression.
-Post-transcriptional control at the message level: message stability, regulation by alternative splicing, editing
-Translational control: external and internal initiation mechanism, regulation strategies
-Post-translational control: Control of protein conformation. Control by protein modification. Protein localisation control. Control of protein degradation
Tutorials
- Analysis of scientific articles related to the course, with presentation by students
Informations complémentaires
Connaissance des principaux mécanismes de régulation de l’expression des gènes : mécanismes de régulation transcriptionnel, post-transcriptionnel, traductionnel et post-traductionnel.
Knowledge of the main mechanisms of regulation of gene expression: transcriptional, post-transcriptional, translational and post-translational regulation mechanisms.